Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory

Ramesh C. Gupta1 *, Rajiv Lall 2, Ajay Srivastava2 and Anita Sinha2 Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF). Hyaluronic acid (HA) content varies widely in different joints and species. HA is a non-sulfated, naturally occurring… Continue reading Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory

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Ajay Srivastava 1, Rajiv Lall 1, Jamil Talukder 1, Dan DuBourdieu 1 and Ramesh C. Gupta 2,*

Coronavirus disease 2019 (COVID
-19) was first officially diagnosed in the city of Wuhan, China
in January 2020. In reality, the disease was identified in December 2019 in
the same city where patients began showing symptoms of pneumonia of unidentified origin. Very soon the disease became a pandemic due to the suppression of information in the country of origin and inadequate
testing for the COVID -19 virus. Currently, more than 36 million people have been found positive
for this virus and more than one million people have died. There are no sign
s that COVID -19 is slowing down . This deadly virus affects multiple vital organs (lungs, heart, nervous system,
blood, and immune system), yet its exact mechanism of pathophysiology remains obscure.
Depending on the viral load, sick people often show symptoms of fever, cough, shortness of
breath, coagulopathy, cardiac abnormalities, fatigue, and death. Great strides have been made in
COVID -19 testing, thereby allowing timely therapeutic intervention. While vaccine development
and clinical trials are underway, prevention and treatment rest with the anti-malarial drug
hydroxychloroquine or chloroquine. Due to a lack of clinical trial -based efficacy and safety of
hydroxychloroquine, its use remains controversial at present. In such a scenario, nutraceuticals and other phyto
-mineral supplements appear to be promising alternative solutions for the prevention and treatment of COVID -19.

 

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Iron Transport Tocopheryl Polyethylene Glycol Succinate in Animal Health and Diseases

Ajay Srivastava 1, Rajiv Lall 1, Jamil Talukder 1, Dan DuBourdieu 1 and Ramesh C. Gupta 2,* 1 Vets Plus, Inc., Menomonie, WI 54751, USA; drajay@vets-plus.com (A.S.); lallr@vets-plus.com (R.L.); jamilt@vets-plus.com (J.T.); dand@vets-plus.com (D.D.) 2 Breathitt Veterinary Center, Toxicology Department, Murray State University, Hopkinsville, KY 42240, USA * Correspondence: rgupta@murraystate.edu Academic Editors: Doriana Tedesco, Aldo Tava… Continue reading Iron Transport Tocopheryl Polyethylene Glycol Succinate in Animal Health and Diseases

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Therapeutic Efficacy and Safety Evaluation of Flex ChoiceTM in Moderately Osteoarthritic Dogs*

Rachael E. Webber1, Ramesh C. Gupta1*, Robin B. Doss1, Jean Miller1, Terry D. Canerdy1, Laura K. Hoffman1, Ajay Srivastava2, Rajiv Lall2 1 Murray State University, Breathitt Veterinary Center, Murray/Hopkinsville, KY, USA. 2 Vets Plus Inc., Menomonie, WI, USA Osteoarthritis (OA) is a chronic inflammatory degenerative joint disease that affects humans and animals alike. Currently, >20%… Continue reading Therapeutic Efficacy and Safety Evaluation of Flex ChoiceTM in Moderately Osteoarthritic Dogs*

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